Search results for "Neoplasias encefálicas"

showing 3 items of 3 documents

Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy

2019

Radiotherapy is a highly effective tool for the treatment of brain cancer. However, radiation also causes detrimental effects in the healthy tissue, leading to neurocognitive sequelae that compromise the quality of life of brain cancer patients. Despite the recognition of this serious complication, no satisfactory solutions exist at present. Here we investigated the effects of intranasal administration of human mesenchymal stem cells (hMSCs) as a neuroprotective strategy for cranial radiation in mice. Our results demonstrated that intranasally delivered hMSCs promote radiation-induced brain injury repair, improving neurological function. This intervention confers protection against inflamma…

0301 basic medicinecognitionmedicine.medical_treatmentneurocognitive sequelaeStem cellsBioinformaticsBrain cancer0302 clinical medicineCognitionOriginal ResearchCREBNeuroprotección:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Radiotherapy [Medical Subject Headings]Neurocognitive sequelaeNeuroprotectionneuroprotectionmedicine.symptomStem cellCélulas madreNeoplasias encefálicas:Diseases::Neoplasms::Neoplasms by Site::Nervous System Neoplasms::Central Nervous System Neoplasms::Brain Neoplasms [Medical Subject Headings]Brain tumorInflammationNeuroprotectionlcsh:RC321-57103 medical and health sciencesCellular and Molecular NeuroscienceRadioterapiastem cellsmedicinelcsh:Neurosciences. Biological psychiatry. Neuropsychiatry:Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Acyltransferases::Acetyltransferases::p300-CBP Transcription Factors::CREB-Binding Protein [Medical Subject Headings]radiotherapybrain cancerCogniciónRadiotherapybusiness.industryMesenchymal stem cellmedicine.diseaseequipment and suppliesIntranasal cell deliveryRadiation therapy030104 developmental biology:Anatomy::Cells::Stem Cells [Medical Subject Headings]Nasal administrationbusinessNeurocognitive030217 neurology & neurosurgeryintranasal cell deliveryNeuroscienceFrontiers in Cellular Neuroscience
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Implications of irradiating the subventricular zone stem cell niche

2016

Radiation therapy is a standard treatment for brain tumor patients. However, it comes with side effects, such as neurological deficits. While likely multi-factorial, the effect may in part be associated with the impact of radiation on the neurogenic niches. In the adult mammalian brain, the neurogenic niches are localized in the subventricular zone (SVZ) of the lateral ventricles and the dentate gyrus of the hippocampus, where the neural stem cells (NSCs) reside. Several reports showed that radiation produces a drastic decrease in the proliferative capacity of these regions, which is related to functional decline. In particular, radiation to the SVZ led to a reduced long-term olfactory memo…

NeurogénesisNeoplasias encefálicasCarcinogenesisSubventricular zoneNeurogenesis:Diseases::Neoplasms::Neoplasms by Site::Nervous System Neoplasms::Central Nervous System Neoplasms::Brain Neoplasms [Medical Subject Headings]Brain tumorSubventricular zoneBrain damageBiologyBrain tumorsArticle03 medical and health sciencesLateral ventricles0302 clinical medicineRadioterapiaLateral VentriclesGliomamedicineAnimalsHumans:Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms Nerve Tissue::Neuroectodermal Tumors::Neoplasms Neuroepithelial::Glioma [Medical Subject Headings]Stem Cell Nichelcsh:QH301-705.5:Anatomy::Cells::Stem Cells::Neural Stem Cells [Medical Subject Headings]Medicine(all)Neural stem cellsRadiationDentate gyrus:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Radiotherapy [Medical Subject Headings]NeurogenesisBrainCell BiologyGeneral MedicineAnatomymedicine.diseaseCélulas-madre neuralesNeural stem cellBrain tumormedicine.anatomical_structurelcsh:Biology (General)nervous system030220 oncology & carcinogenesis:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis::Disease-Free Survival [Medical Subject Headings]medicine.symptomNeuroscience030217 neurology & neurosurgeryDevelopmental BiologyStem Cell Research
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Robustness of PET Radiomics Features: Impact of Co-Registration with MRI

2021

Radiomics holds great promise in the field of cancer management. However, the clinical application of radiomics has been hampered by uncertainty about the robustness of the features extracted from the images. Previous studies have reported that radiomics features are sensitive to changes in voxel size resampling and interpolation, image perturbation, or slice thickness. This study aims to observe the variability of positron emission tomography (PET) radiomics features under the impact of co-registration with magnetic resonance imaging (MRI) using the difference percentage coefficient, and the Spearman’s correlation coefficient for three groups of images: (i) original PET, (ii) PET after co-…

TechnologyTomografía de emisión de positronesNeoplasias encefálicasCorrelation coefficientImagen por resonancia magnética:Phenomena and Processes::Mathematical Concepts::Probability::Uncertainty [Medical Subject Headings]QH301-705.5Computer scienceQC1-999:Diseases::Neoplasms::Neoplasms by Site::Nervous System Neoplasms::Central Nervous System Neoplasms::Brain Neoplasms [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Magnetic Resonance Imaging [Medical Subject Headings]Co registrationFluid-attenuated inversion recovery:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Magnetic resonance imagingRadiomicsRobustness (computer science):Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques Radioisotope::Radionuclide Imaging::Tomography Emission-Computed::Positron-Emission Tomography [Medical Subject Headings]Resamplingradiomics feature robustness; imaging quantification; [11C]-methionine positron emission tomography; PET/MRI co-registration Appl.medicineGeneral Materials ScienceBiology (General)QD1-999InstrumentationSettore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniFluid Flow and Transfer Processesmedicine.diagnostic_testbusiness.industryTPhysicsProcess Chemistry and TechnologyRadiomics feature robustnessGeneral EngineeringPET/MRI co-registrationMagnetic resonance imagingPattern recognitionEngineering (General). Civil engineering (General)Imaging quantificationComputer Science ApplicationsChemistry:Chemicals and Drugs::Amino Acids Peptides and Proteins::Amino Acids::Amino Acids Essential::Methionine [Medical Subject Headings]Positron emission tomography[11C]-methionine positron emission tomography:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings]Artificial intelligenceTA1-2040businessApplied Sciences
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